Ar<tm3(AR)Dmr> Targeted Allele Detail MGI Mouse (MGI:3628492)

Ar^tm3(AR)Dmr
Targeted Allele Detail

Summary

Symbol:	Ar^tm3(AR)Dmr
Name:	androgen receptor; targeted mutation 3, Diane M Robins
MGI ID:	MGI:3628492
Synonyms:	48Q, AR48Q, Ar^tm3Apl
Gene:	Ar Location: ChrX:97192375-97366821 bp, + strand Genetic Position: ChrX, 42.82 cM
Alliance:	Ar^tm3(AR)Dmr page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:108849
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation
description

Allele Type:

Targeted (Humanized sequence, Inserted expressed sequence)

Mutation:

Insertion

Ar^tm3(AR)Dmr expresses 1 gene

Mutation details: Human androgen receptor amino acids 31 to 484 were inserted into the mouse locus. This allele contains 48 glutamine residues in the N terminal. Transient cre expression removed a floxed neo from the recombined locus. RT-PCR demonstrated higher levels of transcript in mutants than wild-type. Western blot showed that protein levels were also somewhat higher. (J:108849)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Ar Mutation:	23 strains or lines available

References

Original:	J:108849 Albertelli MA, et al., Replacing the mouse androgen receptor with human alleles demonstrates glutamine tract length-dependent effects on physiology and tumorigenesis in mice. Mol Endocrinol. 2006 Jun;20(6):1248-60
All:	7 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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