Mpi<Gt(OST90588)Lex> Gene trapped Allele Detail MGI Mouse (MGI:3628756)

Mpi^{Gt(OST90588)Lex}
Gene trapped Allele Detail

Summary

Symbol:	Mpi^{Gt(OST90588)Lex}
Name:	mannose phosphate isomerase; gene trap OST90588, Lexicon Genetics
MGI ID:	MGI:3628756
Synonyms:	Mpi^-, Mpi^{Gt(VICTR48)1Lex}
Gene:	Mpi Location: Chr9:57451539-57460046 bp, - strand Genetic Position: Chr9, 31.05 cM, cytoband C
Alliance:	Mpi^{Gt(OST90588)Lex} page

Mutation
origin

Mutant Cell Line:	OST90588
Germline Transmission:	Earliest citation of germline transmission: J:109220
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector

Mutation details: The insertion of the VICTR48 vector into intron 1 resulted in the splicing of 5' exonic sequences to a neomycin resistance cassette. The vector contained long terminal repeats, neo-pA, BTK and additional LTR sequence. The final product was a fusion of exon 1 and the neo. Protein expression was not detected in mutant embryos. (J:109220)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Mpi Mutation:	32 strains or lines available

References

Original:	J:109220 DeRossi C, et al., Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality. J Biol Chem. 2006 Mar 3;281(9):5916-27
All:	2 reference(s)

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