Fgf10Tg(Myl3-lacZ)24Buck
Transgenic Allele Detail
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| Symbol: |
Fgf10Tg(Myl3-lacZ)24Buck |
| Name: |
fibroblast growth factor 10; transgene insertion 24, Margaret E Buckingham |
| MGI ID: |
MGI:3629660 |
| Synonyms: |
Fgf10-, Fgf10lacZ, Fgf10Mlc1v-nLacZ-v24, Fgf10mlcv, Fgf10Mlcv-nlacZ-v24, Mlc1v-nlacZ-24 |
| Gene: |
Fgf10 Location: Chr13:118851199-118928651 bp, + strand Genetic Position: Chr13, 67.14 cM, cytoband A3-A4
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| Alliance: |
Fgf10Tg(Myl3-lacZ)24Buck page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Hypomorph, Reporter) |
| Mutation: |
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Insertion
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Mutation details: The transgene contains 757 bp upstream of the transcriptional start site, the 5' UTR and the first 33 codons of the mouse myosin light polypeptide 3 gene upstream of nlacZ. The promoter contains a 34 bp deletion at -150 relative to the transcription start site. Two to three copies of the transgene integrated 114 kb upstream of the locus in a head-to-tail array. Expression of the transgene is in a highly similar pattern to that of Fgf10 in the embryo. Whole mount in-situ analysis detected decreased expression of the endogenous gene in homozygous embryos indicating this is a hypomorphic allele.
(J:71788, J:98521)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Fgf10 Mutation: |
33 strains or lines available
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| Original: |
J:71788 Kelly RG, et al., The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm. Dev Cell. 2001 Sep;1(3):435-440 |
| All: |
45 reference(s) |
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Analysis Tools
