Cst5<tm1Hkaw> Targeted Allele Detail MGI Mouse (MGI:3629665)

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Cst5^tm1Hkaw
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Cst5^tm1Hkaw
Name:	cystatin D; targeted mutation 1, Hiroshi Kawaguchi
MGI ID:	MGI:3629665
Synonyms:	Cst10^-
Gene:	Cst5 Location: Chr2:149247242-149252217 bp, + strand Genetic Position: Chr2, 73.8 cM, cytoband G
Alliance:	Cst5^tm1Hkaw page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:109550
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A targeting vector was designed to replace exon 1 with a pgk-neo cassette. Neither transcripts nor protein was detected in mutant rib cartilage. (J:109550)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Cst5 Mutation:	12 strains or lines available

References

Original:	J:109550 Yamada T, et al., Carminerin contributes to chondrocyte calcification during endochondral ossification. Nat Med. 2006 Jun;12(6):665-70
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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