Ptgs2<tm1.1Fun> Targeted Allele Detail MGI Mouse (MGI:3629677)

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Ptgs2^tm1.1Fun
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Ptgs2^tm1.1Fun
Name:	prostaglandin-endoperoxide synthase 2; targeted mutation 1.1, Colin D Funk
MGI ID:	MGI:3629677
Synonyms:	(COX)-2^-, Ptgs2^Y385F, Y371F
Gene:	Ptgs2 Location: Chr1:149975851-149983978 bp, + strand Genetic Position: Chr1, 63.84 cM, cytoband H1
Alliance:	Ptgs2^tm1.1Fun page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:109548
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted
Mutation:		Insertion
		Mutation details: This allele was generated by Cre mediated recombination of Ptgs2^tm1Fun, resulting in the loss of the neomycin selection cassette. (J:109548)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Ptgs2 Mutation:	73 strains or lines available

References

Original:	J:109548 Yu Y, et al., Genetic model of selective COX2 inhibition reveals novel heterodimer signaling. Nat Med. 2006 Jun;12(6):699-704
All:	14 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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