Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(Pomc1-cre)16Lowl
Name:	transgene insertion 16, Bradford B Lowell
MGI ID:	MGI:3640616
Synonyms:	Pomc-Cre, Pomc-Cre(BAC1), Tg(Pomc1-cre)1Lowl
Transgene:	Tg(Pomc1-cre)16Lowl  Location: unknown
Alliance:	Tg(Pomc1-cre)16Lowl page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Pomc1-cre)16Lowl expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Pomc   Mutation details: This transgene consists of a Pomc1 BAC such that cre is driven by Pomc1 regulatory elements. Cre is expressed in POMC neurons in the arcuate nucleus of the hypothalamus and scattered cre activity is also seen in the dentate gyrus of the hippocampus. (J:106354)

Activity:	Tissue activity of this recombinase allele
Driver:	Pomc (species not specified) Summary of all recombinase alleles driven by Pomc. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

31 assay results 1 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Tg(Pomc1-cre)16Lowl

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:106354 Balthasar N, et al., Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron. 2004 Jun 24;42(6):983-91
All:	159 reference(s)