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Tg(Pgk2-cre)24Shb
Transgene Detail
Summary
Symbol: Tg(Pgk2-cre)24Shb
Name: transgene insertion 24, Seiji Shioda
MGI ID: MGI:3641577
Synonyms: Tg(Pgk2-Cre)24Shb
Transgene: Tg(Pgk2-cre)24Shb  Location: unknown  
Alliance: Tg(Pgk2-cre)24Shb page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Pgk2-cre)24Shb expression driven by 1 gene
 
Mutation details: Nucleotides -1404 through +61 of the spermatocyte-specific Pgk2 promoter region were joined to the cDNA encoding Cre recombinase followed by a rabbit globin polyadenylation signal. Expression of cre mRNA in testes was demonstrated by RT-PCR analysis. Double transgenic progeny of a cross of mice with this transgene to animals carrying a loxP-flanked EGFP reporter gene exhibit EGFP fluorescence in spermatocytes and spermatids, but not in spermatogonia or somatic cells of the testis. (J:110868)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pgk2 (species not specified)
Summary of all recombinase alleles driven by Pgk2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Two transgenic mice derived from injected oocytes transmitted the transgene to their progeny. The resultant transgenic mouse lines were designated 3 and 24. Because Cre-mediated recombination sometimes failed to occur in double transgenic progeny of line 3, only line 24 was used.
References
Original:  J:110868 Kido T, et al., The testicular fatty acid binding protein PERF15 regulates the fate of germ cells in PERF15 transgenic mice. Dev Growth Differ. 2005 Jan;47(1):15-24
All:  9 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory