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Cfhr4 Gene Detail
Summary
  • Symbol
    Cfhr4
  • Name
    complement factor H-related 4
  • Synonyms
    Gm4788
  • Feature Type
    protein coding gene
  • IDs
    MGI:3646434
    NCBI Gene: 214403
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:139625657-139708977 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 61.62 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1568 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3646434
 protein coding gene Chr1:139625361-139708981 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016557
 protein coding gene Chr1:143790885-143909049 (-)
A/J MGP_AJ_G0016539
 protein coding gene Chr1:138197038-138263742 (-)
AKR/J MGP_AKRJ_G0016504
 protein coding gene Chr1:142358699-142426855 (-)
BALB/cJ MGP_BALBcJ_G0016500
 protein coding gene Chr1:138546498-138613847 (-)
C3H/HeJ MGP_C3HHeJ_G0016326
 protein coding gene Chr1:142939747-142995340 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016960
 protein coding gene Chr1:148805757-148913244 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0016298
 protein coding gene Chr1:153930083-154022290 (-)
DBA/2J MGP_DBA2J_G0016404
 protein coding gene Chr1:137076273-137664227 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0016475
 protein coding gene Chr1:144704068-145038286 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0016997
 protein coding gene Chr1:142157804-142247412 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CFH, complement factor H
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CFH, complement factor H
  • Synonyms
    AHUS1, AMBP1, ARMD4, ARMS1, CFHL3, FH, FHL1, HF, HF1, HF2, HUS
  • Links
    NCBI Gene ID: 3075
    neXtProt AC: NX_P08603
    UniProt: P08603

  • Chr Location
    1q31.3; chr1:196651754-196752476 (+)  GRCh38
Human Diseases
more
  • Diseases
    17 with human CFH associations

Human Disease Mouse Models
      
IDs
 View 1 model
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 214403 NCBI Gene Model | MGI Sequence Detail 83321 C57BL/6J ±  kb
transcript NM_001029977 RefSeq | MGI Sequence Detail 2887 C57BL/6  
polypeptide NP_001025148 RefSeq | MGI Sequence Detail 879 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • InterPro Domains
    IPR051503 Complement System Regulators and Virion Entry Mediators
    IPR000436 Sushi/SCR/CCP domain
    IPR035976 Sushi/SCR/CCP superfamily
  • GlyGen
    E9Q8B5 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 3
Other
Accession IDs
less
MGI:6456098
References
more
  • Summaries
    All 22
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:116059 Hellwage J, et al., Two factor H-related proteins from the mouse: expression analysis and functional characterization. Immunogenetics. 2006 Nov;58(11):883-93
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory