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Fignl2 Gene Detail
Summary
  • Symbol
    Fignl2
  • Name
    fidgetin-like 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3646919
    NCBI Gene: 668225
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:100948075-100976448 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.39 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    514 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3646919
 protein coding gene Chr15:100948075-100976465 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022363
 protein coding gene Chr15:103075115-103079328 (-)
A/J MGP_AJ_G0022325
 protein coding gene Chr15:99014540-99018747 (-)
AKR/J MGP_AKRJ_G0022301
 protein coding gene Chr15:102023456-102027661 (-)
BALB/cJ MGP_BALBcJ_G0022329
 protein coding gene Chr15:99108550-99113025 (-)
C3H/HeJ MGP_C3HHeJ_G0022099
 protein coding gene Chr15:102116390-102120593 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022777
 protein coding gene Chr15:106922596-106928403 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020302
 protein coding gene Chr15:94740243-94744457 (-)
CAST/EiJ MGP_CASTEiJ_G0021624
 protein coding gene Chr15:102954291-102958509 (-)
CBA/J MGP_CBAJ_G0022068
 protein coding gene Chr15:110609589-110613792 (-)
DBA/2J MGP_DBA2J_G0022195
 protein coding gene Chr15:98342798-98347003 (-)
FVB/NJ MGP_FVBNJ_G0022174
 protein coding gene Chr15:97386031-97390388 (-)
LP/J MGP_LPJ_G0022266
 protein coding gene Chr15:103215731-103219938 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022195
 protein coding gene Chr15:114329268-114333473 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022791
 protein coding gene Chr15:102042171-102046377 (-)
PWK/PhJ MGP_PWKPhJ_G0021363
 protein coding gene Chr15:98491350-98495587 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021195
 protein coding gene Chr15:101938488-101949342 (-)
WSB/EiJ MGP_WSBEiJ_G0021674
 protein coding gene Chr15:102662065-102666271 (-)



Homology
more
  • Human Ortholog
    FIGNL2, fidgetin like 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FIGNL2, fidgetin like 2
  • Links
    NCBI Gene ID: 401720
    neXtProt AC: NX_A6NMB9
    UniProt: A6NMB9

  • Chr Location
    12q13.13; chr12:51817899-51848718 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    3 involving Fignl2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    11 strains or lines available
Conditional knock-out in cultured adult dorsal root ganglion neurons results in longer axons and attenuated growth cone retraction in response to inhibitory molecules.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000095440 Ensembl Gene Model | MGI Sequence Detail 28374 C57BL/6J ±  kb
transcript ENSMUST00000178140 Ensembl | MGI Sequence Detail 4206 Not Applicable  
polypeptide ENSMUSP00000137256 Ensembl | MGI Sequence Detail 644 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 1
References
more
  • Summaries
    All 34
    Diseases 1
    Gene Ontology 2
    Phenotypes 22
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:309596 Baker L, et al., Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration. JCI Insight. 2021 May 10;6(9)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory