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Ifnl2 Gene Detail
Summary
  • Symbol
    Ifnl2
  • Name
    interferon lambda 2
  • Synonyms
    EG330496, Il28a
  • Feature Type
    protein coding gene
  • IDs
    MGI:3647279
    NCBI Gene: 330496
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr7:28208261-28209880 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    159 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3647279
 protein coding gene Chr7:28208209-28209957 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031948
 protein coding gene Chr7:27272568-27306332 (-)
A/J MGP_AJ_G0031927
 protein coding gene Chr7:26656149-26657760 (+)
AKR/J MGP_AKRJ_G0031859
 protein coding gene Chr7:27335961-27337581 (+)
BALB/cJ MGP_BALBcJ_G0031934
 protein coding gene Chr7:26794531-26796142 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0032398
 protein coding gene Chr7:28178889-28185229 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029450
 protein coding gene Chr7:27674710-27708613 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0031619
 protein coding gene Chr7:29473475-29475096 (+)
DBA/2J MGP_DBA2J_G0031772
 protein coding gene Chr7:26413148-26414768 (+)
FVB/NJ MGP_FVBNJ_G0031729
 protein coding gene Chr7:26485723-26487344 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0031764
 protein coding gene Chr7:28948002-28949614 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032429
 protein coding gene Chr7:26771860-26809568 (-)
PWK/PhJ MGP_PWKPhJ_G0030714
 protein coding gene Chr7:21371137-21405599 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0031098
 protein coding gene Chr7:27116251-27155824 (-)



Homology
more
  • Human Ortholog
    IFNL1, interferon lambda 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFNL1, interferon lambda 1
  • Synonyms
    IL-29, IL29
  • Links
    NCBI Gene ID: 282618
    neXtProt AC: NX_Q8IU54
    UniProt: Q8IU54

  • Chr Location
    19q13.2; chr19:39296407-39298673 (+)  GRCh38
  • Human Ortholog
    IFNL2, interferon lambda 2
  • Synonyms
    IFNL2a, IFNL3a, IL-28A, IL28A
  • Links
    NCBI Gene ID: 282616
    neXtProt AC: NX_Q8IZJ0
    UniProt: Q8IZJ0

  • Chr Location
    19q13.2; chr19:39268396-39270188 (+)  GRCh38
  • Human Ortholog
    IFNL3, interferon lambda 3
  • Synonyms
    IFN-lambda-3, IFN-lambda-4, IL-28B, IL28B, IL-28C, IL28C
  • Links
    NCBI Gene ID: 282617
    neXtProt AC: NX_Q8IZI9
    UniProt: Q8IZI9

  • Chr Location
    19q13.2; chr19:39243455-39245250 (-)  GRCh38
Human Diseases
more
  • Diseases
    7 with human IFNL1,IFNL3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059128 Ensembl Gene Model | MGI Sequence Detail 1620 C57BL/6J ±  kb
transcript ENSMUST00000081684 Ensembl | MGI Sequence Detail 702 Not Applicable  
polypeptide ENSMUSP00000080384 Ensembl | MGI Sequence Detail 193 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR029177 Interferon lambda
    IPR038326 Interferon lambda superfamily
  • GlyGen
    Q4VK74 1 site
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 23
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:172800 Pott J, et al., IFN-{lambda} determines the intestinal epithelial antiviral host defense. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7944-9
  • Latest
    J:340288 Ingle H, et al., IFN-lambda derived from nonsusceptible enterocytes acts on tuft cells to limit persistent norovirus. Sci Adv. 2023 Sep 15;9(37):eadi2562
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory