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Wfdc17 Gene Detail
Summary
  • Symbol
    Wfdc17
  • Name
    WAP four-disulfide core domain 17
  • Synonyms
    Amwap, Gm11428
  • Feature Type
    protein coding gene
  • IDs
    MGI:3649773
    NCBI Gene: 100034251
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:83594882-83597095 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.22 cM
Strain
Comparison
more
  • SNPs within 2kb
    341 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3649773
 protein coding gene Chr11:83594817-83597095 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018858
 protein coding gene Chr11:85084811-85087087 (+)
A/J MGP_AJ_G0018825
 protein coding gene Chr11:81837232-81839508 (+)
AKR/J MGP_AKRJ_G0018795
 protein coding gene Chr11:84265444-84267722 (+)
BALB/cJ MGP_BALBcJ_G0018798
 protein coding gene Chr11:82234623-82236900 (+)
C3H/HeJ MGP_C3HHeJ_G0018612
 protein coding gene Chr11:84318185-84320461 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019250
 protein coding gene Chr11:87658934-87661211 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016883
 protein coding gene Chr11:78940366-78942654 (+)
CAST/EiJ MGP_CASTEiJ_G0018167
 protein coding gene Chr11:84937178-84941409 (+)
CBA/J MGP_CBAJ_G0018583
 protein coding gene Chr11:91428352-91430628 (+)
DBA/2J MGP_DBA2J_G0018691
 protein coding gene Chr11:81427916-81430194 (+)
FVB/NJ MGP_FVBNJ_G0018680
 protein coding gene Chr11:80902814-80905091 (+)
LP/J MGP_LPJ_G0018761
 protein coding gene Chr11:85620416-85622692 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018707
 protein coding gene Chr11:91594473-91596750 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019290
 protein coding gene Chr11:84537958-84540235 (+)
PWK/PhJ MGP_PWKPhJ_G0017936
 protein coding gene Chr11:82178997-82181274 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017728
 protein coding gene Chr11:84080586-84082875 (+)
WSB/EiJ MGP_WSBEiJ_G0018218
 protein coding gene Chr11:84388728-84391005 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Targeted
    3
  • Genomic Mutations
    2 involving Wfdc17
  • Find Mice (IMSR)
    9 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    9
  • cDNA Data
    11
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 100034251 NCBI Gene Model | MGI Sequence Detail 2214 C57BL/6J ±  kb
transcript NM_001081957 RefSeq | MGI Sequence Detail 485 Not Specified  
polypeptide NP_001075426 RefSeq | MGI Sequence Detail 76 Not Specified  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR036645 Elafin-like superfamily
    IPR051388 Serine protease inhibitor and venom toxin
    IPR008197 WAP-type 'four-disulfide core' domain
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory