Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Ighg1tm1(cre)Cgn
Name:	immunoglobulin heavy constant gamma 1 (G1m marker); targeted mutation 1, University of Cologne
MGI ID:	MGI:3652526
Synonyms:	Cgamma1-cre, Cy1-cre, IghC gamma1-cre, Ighg1tm1(IRES-cre)Cgn
Gene:	Ighg1  Location: Chr12:113290161-113294143 bp, - strand  Genetic Position: Chr12, 62.1 cM
Alliance:	Ighg1tm1(cre)Cgn page

Germline Transmission:	Earliest citation of germline transmission: J:109583
Parent Cell Line:	IB10/E14IB10 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Ighg1tm1(cre)Cgn expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Ighg1 (MGI:96446)   Mutation details: An IRES-cre was inserted into the 3' region of the Cgamma1 locus between the last membrane-coding exon and its polyadenylation sites. This targeting design allows for the expression from the locus of a bicistronic mRNA consisting of the Cgamma1 and Cre transcript. An FRT site flanked neomycin resistance gene cassette was removed via Flp recombinase expression. (J:109583)

Generation of the Ighg1tm1(cre)Cgn knockin.

Activity:	Tissue activity of this recombinase allele
Driver:	Ighg1 (mouse) Summary of all recombinase alleles driven by Ighg1. Comparative matrix view of recombinase activities Alliance mouse Ighg1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Ighg1tm1(cre)Cgn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ighg1 Mutation:	28 strains or lines available

Original:	J:109583 Casola S, et al., Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7396-401
All:	100 reference(s)