Gnai3<tm1Lbi> Targeted Allele Detail MGI Mouse (MGI:3652743)

Gnai3^tm1Lbi
Targeted Allele Detail

Summary

Symbol:	Gnai3^tm1Lbi
Name:	G protein subunit alpha i3; targeted mutation 1, Lutz Birnbaumer
MGI ID:	MGI:3652743
Gene:	Gnai3 Location: Chr3:108014596-108053462 bp, - strand Genetic Position: Chr3, 46.83 cM
Alliance:	Gnai3^tm1Lbi page

Fusion of lumbar vertebrae in Gnai3^tm1Lbi/Gnai3^tm1Lbi mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:194591
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1^c

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Part of intron 5 and exon 6 were replaced with a neo cassette. (J:68071, J:194591)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Gnai3 Mutation:	28 strains or lines available

References

Original:	J:194591 Jiang M, et al., Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteins. Methods Enzymol. 2002;344:277-98
All:	38 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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