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Macf1tm1Liem
Targeted Allele Detail
Summary
Symbol: Macf1tm1Liem
Name: microtubule-actin crosslinking factor 1; targeted mutation 1, Ronald K H Liem
MGI ID: MGI:3652899
Synonyms: Macf1-
Gene: Macf1  Location: Chr4:123243426-123581331 bp, - strand  Genetic Position: Chr4, 57.42 cM
Alliance: Macf1tm1Liem page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:110693
Parent Cell Line:  CSL3 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette was inserted to replace part of exons 25 and 28 and all of exons 26 and 27. The targeted sequence encoded amino acids 1053-1230, common to all isoforms. (J:110693)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Macf1 Mutation:  854 strains or lines available
References
Original:  J:110693 Chen HJ, et al., The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev. 2006 Jul 15;20(14):1933-45
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory