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Nkx2-1tm2Shk
Targeted Allele Detail
Summary
Symbol: Nkx2-1tm2Shk
Name: NK2 homeobox 1; targeted mutation 2, Shioko Kimura
MGI ID: MGI:3653645
Synonyms: Nkz2-1F, T/ebp(fl)
Gene: Nkx2-1  Location: Chr12:56578741-56583570 bp, - strand  Genetic Position: Chr12, 24.42 cM, cytoband C1-C3
Alliance: Nkx2-1tm2Shk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111027
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A targeting vector was designed to flank exon 2 and insert a floxed neo cassette. The neo was subsequently removed via cre-mediated recombination. (J:111027)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-1 Mutation:  24 strains or lines available
References
Original:  J:111027 Kusakabe T, et al., Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid. Mol Endocrinol. 2006 Aug;20(8):1796-809
All:  26 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory