Ttn<tm1.1Her> Targeted Allele Detail MGI Mouse (MGI:3654306)

Ttn^tm1.1Her
Targeted Allele Detail

Summary

Symbol:	Ttn^tm1.1Her
Name:	titin; targeted mutation 1.1, Joachim Herz
MGI ID:	MGI:3654306
Gene:	Ttn Location: Chr2:76534324-76812891 bp, - strand Genetic Position: Chr2, 45.13 cM, cytoband D
Alliance:	Ttn^tm1.1Her page

Ttn^tm1.1Her/Ttn^tm1.1Her embryos fail to thrive after E9

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:111284
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: Exons 358 (MEx1) and 359 (MEx2) were removed by Cre mediated recombination. In situ hybridization analysis confirms the expression of a truncated protein lacking the kinase domain in homozygous embryos. (J:81993, J:111284)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Ttn Mutation:	1457 strains or lines available

References

Original:	J:111284 Weinert S, et al., M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere. J Cell Biol. 2006 May 22;173(4):559-70
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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