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Tg(Lck-cre)1Jtak
Transgene Detail
Summary
Symbol: Tg(Lck-cre)1Jtak
Name: transgene insertion 1, Junji Takeda
MGI ID: MGI:3655254
Synonyms: Lck-Cre, LckCre, Lck-cre Tg
Transgene: Tg(Lck-cre)1Jtak  Location: unknown  
Alliance: Tg(Lck-cre)1Jtak page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Lck-cre)1Jtak expression driven by 1 gene
    This transgene expresses Cre recombinase under the control of the mouse proximal Lck promoter. (J:67905)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lck (mouse)
Summary of all recombinase alleles driven by Lck.
 

Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
Allelic CompositionGenetic BackgroundCell Line(s)
either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1)
 
involves: 129 * BALB/c * C3H * C57BL/6
 
involves: 129 * BALB/c * C57BL/6
 
involves: 129 * C57BL/6
 
involves: 129 * C57BL/6
 
involves: 129 * C57BL/6
 
involves: 129 * C57BL/6
 
involves: 129 * C57BL/6 * C57BL/6J * DBA/2J
 
involves: 129 * C57BL/6 * C57BL/6J * DBA/2J
 
involves: 129 * C57BL/6 * C57BL/6JWehi * SJL/JWehi
 
involves: 129P2/OlaHsd
 
involves: 129P2/OlaHsd
 
involves: 129P2/OlaHsd
 
involves: 129P2/OlaHsd * C57BL/6
 
involves: 129P2/OlaHsd * C57BL/6
 
involves: 129S1/Sv * 129X1/SvJ
 
involves: 129S4/SvJae * C57BL/6
 
involves: C57BL/6
 
involves: C57BL/6
 
involves: C57BL/6
 
involves: C57BL/6N * FVB/N
 
Not Specified
 
Phenotypes:
Affected Systems
show or hide all annotated terms Sex:
                                         
cellular
abnormal intestinal goblet cell morphology
abnormal cell cycle
increased T cell apoptosis
abnormal leukocyte migration
decreased T cell proliferation
digestive/alimentary system
chronic diarrhea
abnormal intestine morphology
abnormal intestinal goblet cell morphology
intestinal ulcer
abnormal colon morphology
rectal prolapse
abnormal intestinal epithelium physiology
colitis
increased susceptibility to induced colitis
endocrine/exocrine glands
small thymus medulla
decreased thymocyte number
decreased DN2 thymocyte number
decreased DN3 thymocyte number
decreased DN4 thymocyte number
growth/size/body
weight loss
increased susceptibility to weight loss
enlarged spleen
spleen hyperplasia
hematopoietic system
increased T cell apoptosis
abnormal leukocyte migration
small thymus medulla
abnormal T cell morphology
abnormal T cell differentiation
abnormal CD4-positive T cell differentiation
abnormal T-helper 1 cell differentiation
abnormal T-helper 17 cell differentiation
abnormal double-negative T cell morphology
increased double-negative T cell number
arrested T cell differentiation
abnormal T cell number
increased double-positive T cell number
increased CD4-positive, alpha-beta T cell number
increased T-helper 1 cell number
increased CD8-positive, alpha-beta T cell number
abnormal intraepithelial T cell number
increased gamma-delta intraepithelial T cell number
increased memory T cell number
abnormal regulatory T cell number
decreased T cell number
decreased thymocyte number
decreased DN2 thymocyte number
decreased DN3 thymocyte number
decreased DN4 thymocyte number
decreased double-negative T cell number
decreased double-positive T cell number
decreased CD4-positive, alpha-beta T cell number
decreased CD8-positive, alpha-beta T cell number
decreased NK T cell number
decreased regulatory T cell number
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number
absent regulatory T cells
decreased single-positive T cell number
abnormal alpha-beta intraepithelial T cell morphology
abnormal regulatory T cell morphology
abnormal spleen morphology
enlarged spleen
spleen hyperplasia
abnormal CD4-positive, alpha-beta T cell physiology
abnormal T cell activation
decreased T cell proliferation
abnormal regulatory T cell physiology
homeostasis/metabolism
abnormal cytokine level
immune system
N N
immune system phenotype
N N N
increased T cell apoptosis
abnormal leukocyte migration
colitis
increased susceptibility to induced colitis
small thymus medulla
abnormal T cell morphology
abnormal T cell differentiation
abnormal CD4-positive T cell differentiation
abnormal T-helper 1 cell differentiation
abnormal T-helper 17 cell differentiation
abnormal double-negative T cell morphology
increased double-negative T cell number
arrested T cell differentiation
abnormal T cell number
increased double-positive T cell number
increased CD4-positive, alpha-beta T cell number
increased T-helper 1 cell number
increased CD8-positive, alpha-beta T cell number
abnormal intraepithelial T cell number
increased gamma-delta intraepithelial T cell number
increased memory T cell number
abnormal regulatory T cell number
decreased T cell number
decreased thymocyte number
decreased DN2 thymocyte number
decreased DN3 thymocyte number
decreased DN4 thymocyte number
decreased double-negative T cell number
decreased double-positive T cell number
decreased CD4-positive, alpha-beta T cell number
decreased CD8-positive, alpha-beta T cell number
decreased NK T cell number
decreased regulatory T cell number
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number
absent regulatory T cells
decreased single-positive T cell number
abnormal alpha-beta intraepithelial T cell morphology
abnormal regulatory T cell morphology
abnormal spleen morphology
enlarged spleen
spleen hyperplasia
abnormal CD4-positive, alpha-beta T cell physiology
abnormal T cell activation
decreased T cell proliferation
abnormal regulatory T cell physiology
abnormal cytokine level
absent follicular dendritic cells
enlarged lymph nodes
decreased interferon-gamma secretion
increased interferon-gamma secretion
increased interleukin-17 secretion
decreased interleukin-2 secretion
decreased susceptibility to experimental autoimmune encephalomyelitis
decreased susceptibility to induced arthritis
liver/biliary system
abnormal liver morphology
mortality/aging
neonatal lethality, incomplete penetrance
neoplasm
increased lymphoma incidence
skeleton
decreased susceptibility to induced arthritis
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
References
Original:  J:67905 Takahama Y, et al., Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene. Eur J Immunol. 1998 Jul;28(7):2159-66
All:  82 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory