Arf6<tm1Yaka> Targeted Allele Detail MGI Mouse (MGI:3662650)

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Arf6^tm1Yaka
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Arf6^tm1Yaka
Name:	ARF GTPase 6; targeted mutation 1, Yasunori Kanaho
MGI ID:	MGI:3662650
Synonyms:	Arf6^-
Gene:	Arf6 Location: Chr12:69418924-69420557 bp, + strand Genetic Position: Chr12, 28.81 cM
Alliance:	Arf6^tm1Yaka page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:111404
Parent Cell Line:	E14K (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A vector was designed to replace a fragment encompassing the ATG with a neomycin resistance cassette. Western blot failed to detect protein in mutant MEFs. (J:111404)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Arf6 Mutation:	10 strains or lines available

References

Original:	J:111404 Suzuki T, et al., Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol Cell Biol. 2006 Aug;26(16):6149-56
All:	4 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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