Coro1a<tm1Achn> Targeted Allele Detail MGI Mouse (MGI:3664599)

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Coro1a^tm1Achn
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Coro1a^tm1Achn
Name:	coronin, actin binding protein 1A; targeted mutation 1, Andrew C Chan
MGI ID:	MGI:3664599
Synonyms:	coronin 1^-
Gene:	Coro1a Location: Chr7:126298946-126303925 bp, - strand Genetic Position: Chr7, 69.25 cM, cytoband F3
Alliance:	Coro1a^tm1Achn page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:111593
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exons 2 through 10 were replaced with a neomycin resistance cassette. No Coro1a protein was detected in thymocytes, splenocytes, or bone marrow-derived cells. (J:111593)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Coro1a Mutation:	25 strains or lines available

References

Original:	J:111593 Foger N, et al., Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis. Science. 2006 Aug 11;313(5788):839-42
All:	4 reference(s)

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