Tbx1<tm5Bld> Targeted Allele Detail MGI Mouse (MGI:3664784)

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Tbx1^tm5Bld
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Tbx1^tm5Bld
Name:	T-box 1; targeted mutation 5, Antonio Baldini
MGI ID:	MGI:3664784
Synonyms:	Tbx1^neo2
Gene:	Tbx1 Location: Chr16:18399729-18409412 bp, - strand Genetic Position: Chr16, Syntenic
Alliance:	Tbx1^tm5Bld page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:112457
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1^b-m2

Mutation
description

Allele Type:		Targeted (Conditional ready, Hypomorph)
Mutation:		Insertion
		Mutation details: A floxed neo was inserted into intron 5. This is a hypomorphic allele that can revert to a functional allele upon Cre recombination. (J:112457)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	36 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Tbx1 Mutation:	36 strains or lines available

References

Original:	J:112457 Zhang Z, et al., Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development. Development. 2006 Sep;133(18):3587-95
All:	7 reference(s)

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