Etn3Ppd
Spontaneous Allele Detail
|
|
| Symbol: |
Etn3Ppd |
| Name: |
early transposon element insertion site 3; polypodia |
| MGI ID: |
MGI:3665247 |
| Gene: |
Etn3 Location: unknown Genetic Position: ChrX, Syntenic
|
| Alliance: |
Etn3Ppd page
|
|
Polypodia caudal appendicular skeletal malformations in Ppd/Y and Ppd/? mice.
Show the 2 phenotype image(s) involving this allele.
|
|
|
|
|
| Allele Type: |
|
Spontaneous |
| Mutation: |
|
Transposon insertion
|
| |
|
Mutation details: A novel type II early transposon (ETnIIbeta) spontaneously inserted 1.6 Kb downstream of the polyadenylation signal of Dusp9 between two repetitive sequences (SINE and LINE elements) at position ChrX: 73645160 (GRCm38/mm10). This insertion does not disrupt Dusp9, Pnck or any other gene or noncoding RNA. RT-PCR and western blot analysis confirmed increased Dusp9 transcript and protein expression, respectively, in mutant ES cells.
(J:207896)
|
| Inheritance: |
|
Dominant |
|
Location and orientation of the transposon insertion in the Etn3Ppd allele |
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Etn3 Mutation: |
1 strain or line available
|
|
| Original: |
J:112867 Lehoczky JA, et al., Description and genetic mapping of Polypodia: an X-linked dominant mouse mutant with ectopic caudal limbs and other malformations. Mamm Genome. 2006 Sep;17(9):903-13 |
| All: |
2 reference(s) |
|
Analysis Tools
