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Tg(Col2a1-cre/ERT)KA3Smac
Transgene Detail
Summary
Symbol: Tg(Col2a1-cre/ERT)KA3Smac
Name: transgene insertion KA3, Susan Mackem
MGI ID: MGI:3665440
Synonyms: Col2CreERT, Tg(Col2a1-cre/ESR1)1Smac, Tg(Col2a1-cre/ESR1)KA3Smac
Transgene: Tg(Col2a1-cre/ERT)KA3Smac  Location: unknown  
Alliance: Tg(Col2a1-cre/ERT)KA3Smac page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Col2a1-cre/ERT)KA3Smac expression driven by 1 gene
 
Mutation details: This transgene expresses a tamoxifen-inducible form of cre recombinase driven by the Col2a1 promoter in cartilage. The cre recombinase coding region is joined to a sequence encoding the ligand-binding domain of the human estrogen receptor with glycine to arginine missense mutation at position 521. This substitution enables the domain to bind to tamoxifen while ablating the estradiol binding ability. (J:111627)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Col2a1 (species not specified)
Summary of all recombinase alleles driven by Col2a1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:111627 Nakamura E, et al., Kinetics of tamoxifen-regulated Cre activity in mice using a cartilage-specific CreER(T) to assay temporal activity windows along the proximodistal limb skeleton. Dev Dyn. 2006 Aug 7;235(9):2603-2612
All:  82 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory