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Gzmmtm1(cre)Mjs
Targeted Allele Detail
Summary
Symbol: Gzmmtm1(cre)Mjs
Name: granzyme M (lymphocyte met-ase 1); targeted mutation 1, Mark J Smyth
MGI ID: MGI:3665444
Synonyms: GrzM-, GrzM cre
Gene: Gzmm  Location: Chr10:79524854-79531095 bp, + strand  Genetic Position: Chr10, 39.72 cM, cytoband C
Alliance: Gzmmtm1(cre)Mjs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:113213
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Gzmmtm1(cre)Mjs expression driven by 1 gene
 
Mutation details: Cre recombinase cDNA was inserted directly upstream of the ATG in exon 1. An frt-flanked neo was included in the vector and was removed in vivo. RT-PCR demonstrated expression of cre in the mutant mice and the absence of full-length Gzmm transcript in mutants. (J:113213)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gzmm (mouse)
Summary of all recombinase alleles driven by Gzmm.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gzmm Mutation:  7 strains or lines available
References
Original:  J:113213 Pao LI, et al., Functional analysis of granzyme M and its role in immunity to infection. J Immunol. 2005 Sep 1;175(5):3235-43
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory