Ptpn11<tm1Yan> Targeted Allele Detail MGI Mouse (MGI:3690333)

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Ptpn11^tm1Yan
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Ptpn11^tm1Yan
Name:	protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1, Wentian Yang
MGI ID:	MGI:3690333
Synonyms:	Ptpn11EX11_floxed, Ptpn11^tm1Ambt, SHP-2 (lox)
Gene:	Ptpn11 Location: Chr5:121268596-121329460 bp, - strand Genetic Position: Chr5, 61.72 cM, cytoband F
Alliance:	Ptpn11^tm1Yan page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:114499
Parent Cell Line:	ESVJ-1182 (ES Cell)
Strain of Origin:	129X1/SvJ

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		LoxP sites were inserted to flank exon 11, which encodes the catalytic motif. (J:114499)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Ptpn11 Mutation:	46 strains or lines available

References

Original:	J:114499 Fornaro M, et al., SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth. J Cell Biol. 2006 Oct 9;175(1):87-97
All:	8 reference(s)

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