Fktntm2(FCMD)Ttd
Targeted Allele Detail
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| Symbol: |
Fktntm2(FCMD)Ttd |
| Name: |
fukutin; targeted mutation 2, Tatsushi Toda |
| MGI ID: |
MGI:3690337 |
| Synonyms: |
FtknHp |
| Gene: |
Fktn Location: Chr4:53713745-53765785 bp, + strand Genetic Position: Chr4, 28.74 cM
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| Alliance: |
Fktntm2(FCMD)Ttd page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:114512
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Fktntm2(FCMD)Ttd expresses
1 gene
Knock-in expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
FKTN (2218) |
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Mutation details: Exon 10 was removed from the locus via Cre mediated expression following the insertion of lox71 and loxP sites. Human FCMD exon 10 cDNA from a patient with Fukuyama Congenital Muscular Dystrophy with the causative retrotransposon was inserted between the lox66 and loxP sites of the targeting construct. Transcript expression level is 5% to 10% of normal.
(J:114512)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Fktn Mutation: |
44 strains or lines available
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| Original: |
J:114512 Xiong H, et al., Molecular interaction between fukutin and POMGnT1 in the glycosylation pathway of alpha-dystroglycan. Biochem Biophys Res Commun. 2006 Dec 1;350(4):935-41 |
| All: |
5 reference(s) |
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Analysis Tools
