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Tlr3tm1Aki
Targeted Allele Detail
Summary
Symbol: Tlr3tm1Aki
Name: toll-like receptor 3; targeted mutation 1, Shizuo Akira
MGI ID: MGI:3690535
Synonyms: Tlr3-, Tlr3tm1Ttg
Gene: Tlr3  Location: Chr8:45848702-45864112 bp, - strand  Genetic Position: Chr8, 25.31 cM, cytoband B2
Alliance: Tlr3tm1Aki page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:114555
Parent Cell Line:  E14.1TG3B1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    The third and fourth exons of the coding region were replaced with a neomycin resistance cassette. (J:114555)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tlr3 Mutation:  68 strains or lines available
References
Original:  J:114555 Honda K, et al., Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10872-7
All:  77 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory