Cd151<tm1Nki> Targeted Allele Detail MGI Mouse (MGI:3691076)

Cd151^tm1Nki
Targeted Allele Detail

Summary

Symbol:	Cd151^tm1Nki
Name:	CD151 antigen; targeted mutation 1, The Netherlands Cancer Institute
MGI ID:	MGI:3691076
Synonyms:	Cd151^-, Cd151^tm1Son
Gene:	Cd151 Location: Chr7:141047305-141051386 bp, + strand Genetic Position: Chr7, 86.82 cM
Alliance:	Cd151^tm1Nki page

Glomerular basement membrane abnormalities and foot process effacement in kidneys of mildly affected Cd151^tm1Nki/Cd151^tm1Nki and Itga3^tm1Son/Itga3^tm1Son Tg(NPHS2-cre)295Lbh/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:114988
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked puromycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Exons 2-4 were removed via cre-mediated recombination. Immunoblot failed to detect protein in mutant MEFs. The final allele lacks the puromycin resistance cassette. The floxed allele Cd151^tm2Nki was used to generate this allele. (J:114988)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
hm1	Cd151^tm1Nki/Cd151^tm1Nki	involves: 129P2/OlaHsd * FVB/N

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
cardiovascular system	√
abnormal glomerular capillary morphology	√
abnormal glomerular capillary endothelium morphology	√
abnormal glomerular endothelium fenestra morphology	√
cellular	√
increased mesangial cell number	√
growth/size/body	√
weight loss	√
hearing/vestibular/ear	N
hearing/vestibular/ear phenotype	N
homeostasis/metabolism	√
increased urine protein level	√
albuminuria	√
immune system	√
tubulointerstitial nephritis	√
integument	N
integument phenotype	N
renal/urinary system	√
increased urine protein level	√
albuminuria	√
tubulointerstitial nephritis	√
abnormal kidney morphology	√
abnormal renal glomerular capsule morphology	√
absent podocyte foot process	√
podocyte foot process effacement	√
absent podocyte slit diaphragm	√
abnormal renal glomerulus basement membrane morphology	√
increased renal glomerulus basement membrane thickness	√
abnormal renal glomerulus morphology	√
abnormal glomerular capillary morphology	√
abnormal glomerular capillary endothelium morphology	√
abnormal glomerular endothelium fenestra morphology	√
increased mesangial cell number	√
expanded mesangial matrix	√
glomerulosclerosis	√
glomerular crescent	√
renal glomerular synechia	√
renal interstitial fibrosis	√
kidney atrophy	√
abnormal proximal convoluted tubule morphology	√
dilated proximal convoluted tubule	√
renal cast	√
granular kidney	√
kidney degeneration	√
kidney failure	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Cd151 Mutation:	35 strains or lines available

References

Original:	J:114988 Sachs N, et al., Kidney failure in mice lacking the tetraspanin CD151. J Cell Biol. 2006 Oct 9;175(1):33-9
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24