Cd151<tm1Nki> Targeted Allele Detail MGI Mouse (MGI:3691076)

Cd151^tm1Nki
Targeted Allele Detail

Summary

Symbol:	Cd151^tm1Nki
Name:	CD151 antigen; targeted mutation 1, The Netherlands Cancer Institute
MGI ID:	MGI:3691076
Synonyms:	Cd151^-, Cd151^tm1Son
Gene:	Cd151 Location: Chr7:141047305-141051386 bp, + strand Genetic Position: Chr7, 86.82 cM
Alliance:	Cd151^tm1Nki page

Glomerular basement membrane abnormalities and foot process effacement in kidneys of mildly affected Cd151^tm1Nki/Cd151^tm1Nki and Itga3^tm1Son/Itga3^tm1Son Tg(NPHS2-cre)295Lbh/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:114988
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked puromycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Exons 2-4 were removed via cre-mediated recombination. Immunoblot failed to detect protein in mutant MEFs. The final allele lacks the puromycin resistance cassette. The floxed allele Cd151^tm2Nki was used to generate this allele. (J:114988)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Cd151 Mutation:	34 strains or lines available

References

Original:	J:114988 Sachs N, et al., Kidney failure in mice lacking the tetraspanin CD151. J Cell Biol. 2006 Oct 9;175(1):33-9
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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