Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Slc6a3tm1(cre)Xz
Name:	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1, Xiaoxi Zhuang
MGI ID:	MGI:3691571
Synonyms:	DAT-cre, Slc6a3Cre
Gene:	Slc6a3  Location: Chr13:73684866-73726791 bp, + strand  Genetic Position: Chr13, 40.1 cM
Alliance:	Slc6a3tm1(cre)Xz page

Germline Transmission:	Earliest citation of germline transmission: J:115426
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Slc6a3tm1(cre)Xz expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Slc6a3 (MGI:94862)   Mutation details: A targeting vector was constructed by inserting a cassette with the cre recombinase coding sequence, a nuclear translocation signal, and a PGK-neo gene flanked by FRT sites, into the 5'-UTR of the Slc6a3 gene. After homologous recombination in ES cells, mice with cre recombinase expressed from the Slc6a3 gene were produced. Knockin mice were crossed with transgenic Flp deleter mice to remove the neo marker. A line was established where the neo was removed and the Flp transgene was absent. Cre recombinase expression is detected in the ventral tegmental area (VAT) and substantia nigra zona compacta (SNc). (J:115426)

Activity:	Tissue activity of this recombinase allele
Driver:	Slc6a3 (mouse) Summary of all recombinase alleles driven by Slc6a3. Comparative matrix view of recombinase activities Alliance mouse Slc6a3 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

14 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Slc6a3 Mutation:	66 strains or lines available

Original:	J:115426 Zhuang X, et al., Targeted gene expression in dopamine and serotonin neurons of the mouse brain. J Neurosci Methods. 2005 Apr 15;143(1):27-32
All:	101 reference(s)