Boc<tm1Aok> Targeted Allele Detail MGI Mouse (MGI:3692939)

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Boc^tm1Aok
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Boc^tm1Aok
Name:	BOC cell adhesion associated, oncogene regulated; targeted mutation 1, Ami Okada
MGI ID:	MGI:3692939
Synonyms:	Boc^-
Gene:	Boc Location: Chr16:44305408-44379233 bp, - strand Genetic Position: Chr16, 28.81 cM, cytoband B5
Alliance:	Boc^tm1Aok page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:115577
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: Homologous recombination was used to insert a gene trap vector encoding a strong splice acceptor site, transmembrane domain and beta-geo followed by an IRES-PLAP upstream of the exon encoding the transmembrane domain. The allele proved to be severely hypomorphic. (J:115577)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

9 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Boc Mutation:	61 strains or lines available

References

Original:	J:115577 Okada A, et al., Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature. 2006 Nov 16;444(7117):369-73
All:	14 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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