Tg(Slc5a2-cre)1Tauc
Transgene Detail
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| Symbol: |
Tg(Slc5a2-cre)1Tauc |
| Name: |
transgene insertion 1, Michel Tauc |
| MGI ID: |
MGI:3694735 |
| Synonyms: |
iL1-sglt2-Cre, mSglt2 5pr-mut-Cre |
| Transgene: |
Tg(Slc5a2-cre)1Tauc Location: unknown
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| Alliance: |
Tg(Slc5a2-cre)1Tauc page
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Slc5a2-cre)1Tauc expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Slc5a2 |
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Mutation details: The transgene expresses Cre recombinase under control of the promoter region of the gene encoding solute carrier family 5 (sodium/glucose cotransporter), member 2, including 1952 bp of 5'-flanking sequence, the first exon (containing a mutated translation initiation codon), first intron and 23 bp of the second exon. X-gal staining of multiple tissues from mice doubly transgenic for this transgene and for the E. coli beta-galactosidase gene (lacZ) preceded by a loxP-flanked stop sequence (knocked into the Gt(ROSA)26Sor locus) demonstrated beta-galactosidase activity only in the kidney. Immunohistochemical analysis of X-gal-stained kidney cryostat sections for markers specific to different regions of the nephron showed colocalization of X-gal staining only with anti-megalin antibody, which identifies the proximal tubules.
(J:111666)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Slc5a2
(species not specified)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:111666 Rubera I, et al., Specific Cre/Lox recombination in the mouse proximal tubule. J Am Soc Nephrol. 2004 Aug;15(8):2050-6 |
| All: |
22 reference(s) |
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Analysis Tools
