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Ptcratm1(icre)Hjf
Targeted Allele Detail
Summary
Symbol: Ptcratm1(icre)Hjf
Name: pre T cell antigen receptor alpha; targeted mutation 1, Hans Jorg Fehling
MGI ID: MGI:3696089
Synonyms: pTa/iCre, Ptcratm1(cre)Hjf
Gene: Ptcra  Location: Chr17:47066589-47074638 bp, - strand  Genetic Position: Chr17, 22.9 cM, cytoband D-E1
Alliance: Ptcratm1(icre)Hjf page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117041
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Ptcratm1(icre)Hjf expression driven by 1 gene
 
Mutation details: A mini-gene encoding a codon-optimized cre, the SV40 polyadenylation signal and an Frt-flanked neo selection cassette was inserted into the first exon of the Ptcra (pTalpha) gene in ES cells. The neo was excised in vitro by transient transfection with flippase. Expression of cre is observed in immature DP thymocytes and in more mature SP cells. (J:117041, J:197923)
Generation of the Ptcratm1(icre)Hjf allele
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ptcra (mouse)
Summary of all recombinase alleles driven by Ptcra.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ptcra Mutation:  16 strains or lines available
References
Original:  J:117041 Luche H, et al., Faithful activation of an extra-bright red fluorescent protein in 'knock-in' Cre-reporter mice ideally suited for lineage tracing studies. Eur J Immunol. 2007 Jan;37(1):43-53
All:  11 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory