Glra1<tm1Betz> Targeted Allele Detail MGI Mouse (MGI:3696673)

Glra1^tm1Betz
Targeted Allele Detail

Summary

Symbol:	Glra1^tm1Betz
Name:	glycine receptor, alpha 1 subunit; targeted mutation 1, Heinrich Betz
MGI ID:	MGI:3696673
Synonyms:	Glra1(D80A)
Gene:	Glra1 Location: Chr11:55405065-55499024 bp, - strand Genetic Position: Chr11, 33.12 cM
Alliance:	Glra1^tm1Betz page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:117236
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted
Mutation:		Nucleotide substitutions
		The D80A substitution was inserted into exon 4. (J:117236)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Glra1 Mutation:	30 strains or lines available

References

Original:	J:117236 Hirzel K, et al., Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission. Neuron. 2006 Nov 22;52(4):679-90
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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