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Gata3tm3Gsv
Targeted Allele Detail
Summary
Symbol: Gata3tm3Gsv
Name: GATA binding protein 3; targeted mutation 3, Frank G Grosveld
MGI ID: MGI:3696958
Synonyms: Gata3cko, Gata3fl
Gene: Gata3  Location: Chr2:9861889-9894845 bp, - strand  Genetic Position: Chr2, 6.69 cM
Alliance: Gata3tm3Gsv page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117058
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A targeting vector was designed to insert loxP sites into the start codon in exon 2 and in intron 2. A puromycin resistance cassette, flanked by FRT sites was coupled to an nlsLacZ gene in intron 2. Transient expression of Flp recombinase resulted in removal of the puro cassette. Upon cre mediated excision, the 5' end of exon 2 is removed as well as intron 2 sequence upstream of the nlslacZ. This allows the reporter to be expressed under endogenous control. (J:117058)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 17 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata3 Mutation:  32 strains or lines available
References
Original:  J:117058 Kurek D, et al., Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles. Development. 2007 Jan;134(2):261-72
All:  13 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory