About   Help   FAQ
Lmx1btm1Zfc
Targeted Allele Detail
Summary
Symbol: Lmx1btm1Zfc
Name: LIM homeobox transcription factor 1 beta; targeted mutation 1, Zhou-Feng Chen
MGI ID: MGI:3696968
Synonyms: Lmx1bf, Lmx1bflox
Gene: Lmx1b  Location: Chr2:33450977-33530620 bp, - strand  Genetic Position: Chr2, 22.48 cM
Alliance: Lmx1btm1Zfc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:116706
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: This allele contains loxP sites flanking exons 3-7, which contain sequence encoding the second LIM domain, the homeodomain and most of the carboxy-terminal region. (J:116706)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 104108 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmx1b Mutation:  16 strains or lines available
References
Original:  J:116706 Zhao ZQ, et al., Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. J Neurosci. 2006 Dec 6;26(49):12781-8
All:  32 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory