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Lmx1btm1Zfc
Targeted Allele Detail
Summary
Symbol: Lmx1btm1Zfc
Name: LIM homeobox transcription factor 1 beta; targeted mutation 1, Zhou-Feng Chen
MGI ID: MGI:3696968
Synonyms: Lmx1bf, Lmx1bflox
Gene: Lmx1b  Location: Chr2:33450977-33530620 bp, - strand  Genetic Position: Chr2, 22.48 cM
Alliance: Lmx1btm1Zfc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:116706
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: This allele contains loxP sites flanking exons 3-7, which contain sequence encoding the second LIM domain, the homeodomain and most of the carboxy-terminal region. (J:116706)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 104108 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmx1b Mutation:  16 strains or lines available
References
Original:  J:116706 Zhao ZQ, et al., Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. J Neurosci. 2006 Dec 6;26(49):12781-8
All:  32 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory