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Alkal2 Gene Detail
Summary
  • Symbol
    Alkal2
  • Name
    ALK and LTK ligand 2
  • Synonyms
    6230419C23Rik, Augalpha, Augmentor alpha, Fam150b
  • Feature Type
    protein coding gene
  • IDs
    MGI:3697448
    NCBI Gene: 100294583
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:30934323-30943855 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 13.00 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    269 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3697448
 protein coding gene Chr12:30934321-30943855 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019653
 protein coding gene Chr12:28802749-28812418 (+)
A/J MGP_AJ_G0019620
 protein coding gene Chr12:27996558-28006226 (+)
AKR/J MGP_AKRJ_G0019591
 protein coding gene Chr12:28899138-28908806 (+)
BALB/cJ MGP_BALBcJ_G0019597
 protein coding gene Chr12:28240384-28250052 (+)
C3H/HeJ MGP_C3HHeJ_G0019401
 protein coding gene Chr12:28758246-28767896 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020044
 protein coding gene Chr12:29696261-29707627 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017669
 protein coding gene Chr12:27317955-27327457 (+)
CAST/EiJ MGP_CASTEiJ_G0018956
 protein coding gene Chr12:23764400-23773964 (+)
CBA/J MGP_CBAJ_G0019372
 protein coding gene Chr12:30669017-30678685 (+)
DBA/2J MGP_DBA2J_G0019486
 protein coding gene Chr12:27831543-27841194 (+)
FVB/NJ MGP_FVBNJ_G0019477
 protein coding gene Chr12:27629582-27639235 (+)
LP/J MGP_LPJ_G0019556
 protein coding gene Chr12:28891517-28901459 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019512
 protein coding gene Chr12:30294297-30303932 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020084
 protein coding gene Chr12:28419266-28428905 (+)
PWK/PhJ MGP_PWKPhJ_G0018723
 protein coding gene Chr12:22570112-22579678 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018511
 protein coding gene Chr12:23041190-23050666 (+)
WSB/EiJ MGP_WSBEiJ_G0019007
 protein coding gene Chr12:28656734-28666393 (+)



Homology
more
  • Human Ortholog
    ALKAL2, ALK and LTK ligand 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALKAL2, ALK and LTK ligand 2
  • Synonyms
    AUGA, FAM150B, PRO1097, RGPG542
  • Links
    NCBI Gene ID: 285016
    neXtProt AC: NX_Q6UX46
    UniProt: Q6UX46

  • Chr Location
    2p25.3; chr2:279558-288851 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous deletion of this gene results in slow postnatal weight gain, thin body, decreased adiposity, and leanness coupled to increased energy expenditure and respiratory exchange ratio, hyperactivity, improved glucose tolerance and sensitivity to insulin, and decreased susceptibility to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    13
  • cDNA Data
    3
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100294583 NCBI Gene Model | MGI Sequence Detail 9533 C57BL/6J ±  kb
    transcript NM_001159743 RefSeq | MGI Sequence Detail 1509 C57BL/6  
    polypeptide Q80UG6 UniProt | EBI | MGI Sequence Detail 151 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 3
      Primer pair 1
    Other
    Accession IDs
    less
    MGI:5897450
    References
    more
    • Summaries
      All 24
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 5
    • Earliest
      J:216664 Zhang H, et al., Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15741-5
    • Latest
      J:338243 Christova T, et al., LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity. EMBO Rep. 2023 Jul 5;24(7):e56937
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory