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Dmrtc2tm1(cre)Knis
Targeted Allele Detail
Summary
Symbol: Dmrtc2tm1(cre)Knis
Name: doublesex and mab-3 related transcription factor like family C2; targeted mutation 1, Katsuhiko Nishimori
MGI ID: MGI:3697743
Synonyms: Dmrt7-, Dmrt7tm1(cre)Knis
Gene: Dmrtc2  Location: Chr7:24569482-24577076 bp, + strand  Genetic Position: Chr7, 13.33 cM, cytoband A3
Alliance: Dmrtc2tm1(cre)Knis page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117721
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Dmrtc2tm1(cre)Knis expression driven by 1 gene
 
Mutation details: Exons 2 and 3 were replaced with cre recombinase and a neomycin resistance cassette in-frame. Northern blot confirmed absence of transcript in mutant testes. (J:117721)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Dmrtc2 (mouse)
Summary of all recombinase alleles driven by Dmrtc2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dmrtc2 Mutation:  13 strains or lines available
References
Original:  J:117721 Kawamata M, et al., Mice deficient in Dmrt7 show infertility with spermatogenic arrest at pachytene stage. FEBS Lett. 2006 Nov 27;580(27):6442-6
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory