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Hsd11b2tm1(cre)Anft
Targeted Allele Detail
Summary
Symbol: Hsd11b2tm1(cre)Anft
Name: hydroxysteroid 11-beta dehydrogenase 2; targeted mutation 1, Aniko Naray-Fejes-Toth
MGI ID: MGI:3699113
Synonyms: 11HSD2/iCre, Hsd11b2-Cre
Gene: Hsd11b2  Location: Chr8:106245387-106250620 bp, + strand  Genetic Position: Chr8, 53.04 cM
Alliance: Hsd11b2tm1(cre)Anft page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:118075
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Hsd11b2tm1(cre)Anft expression driven by 1 gene
 
Mutation details: An improved Cre and a neomycin resistance cassette were inserted to replace the exon containing the ATG. The neo was flanked by FRT sites and subsequently removed by FLP mediated recombination. (J:118075)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Hsd11b2 (mouse)
Summary of all recombinase alleles driven by Hsd11b2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsd11b2 Mutation:  19 strains or lines available
References
Original:  J:118075 Naray-Fejes-Toth A, et al., Novel mouse strain with Cre recombinase in 11beta-hydroxysteroid dehydrogenase-2-expressing cells. Am J Physiol Renal Physiol. 2007 Jan;292(1):F486-94
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory