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Chrna4tm1Jbou
Targeted Allele Detail
Summary
Symbol: Chrna4tm1Jbou
Name: cholinergic receptor, nicotinic, alpha polypeptide 4; targeted mutation 1, Jim Boulter
MGI ID: MGI:3700204
Synonyms: Chrna4S252F
Gene: Chrna4  Location: Chr2:180664104-180685339 bp, - strand  Genetic Position: Chr2, 103.54 cM
Alliance: Chrna4tm1Jbou page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:118273
Parent Cell Line:  GSI-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
 
Mutation details: The S252F mutation was introduced. A floxed neo was removed from the locus via cre mediated recombination. (J:118273)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chrna4 Mutation:  44 strains or lines available
References
Original:  J:118273 Klaassen A, et al., Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy. Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19152-7
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory