Acaca<tm1Jkus> Targeted Allele Detail MGI Mouse (MGI:3700954)

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Acaca^tm1Jkus
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Acaca^tm1Jkus
Name:	acetyl-Coenzyme A carboxylase alpha; targeted mutation 1, Jun Kusunokie
MGI ID:	MGI:3700954
Synonyms:	Acc1^lox(ex46)
Gene:	Acaca Location: Chr11:84020498-84292477 bp, + strand Genetic Position: Chr11, 51.29 cM
Alliance:	Acaca^tm1Jkus page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:118861
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Exon 46 was flanked with loxP sites while a floxed PGK-neo cassette was inserted into intron 46. (J:118861)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Acaca Mutation:	128 strains or lines available

References

Original:	J:118861 Harada N, et al., Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice. Mol Cell Biol. 2007 Mar;27(5):1881-8
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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