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Tg(Lck-cre)I540Jxm
Transgene Detail
Summary
Symbol: Tg(Lck-cre)I540Jxm
Name: transgene insertion I540, Jamey Marth
MGI ID: MGI:3701502
Transgene: Tg(Lck-cre)I540Jxm  Location: unknown  
Alliance: Tg(Lck-cre)I540Jxm page
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F2
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Lck-cre)I540Jxm expression driven by 1 gene
 
Mutation details: The Cre recombinase coding sequence, modified by addition of a Kozak consensus translation start sequence and nuclear localization signals, was inserted into the p1017 expression vector between the thymocyte-specific, mouse proximal Lck promoter and most of the human growth hormone gene, extending from within exon 1 through the polyadenylation signal. Cre recombinase activity is restricted to thymocytes; evidence of activity in spleen is attributed to the presence of thymus-derived T lymphocytes. (J:67674, J:81268)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lck (mouse)
Summary of all recombinase alleles driven by Lck.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:67674 Hennet T, et al., T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12070-4
All:  18 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory