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Tg(Emx1-cre)1Ito
Transgene Detail
Summary
Symbol: Tg(Emx1-cre)1Ito
Name: transgene insertion 1, Shigeyoshi Itohara
MGI ID: MGI:3701617
Synonyms: Tg1
Transgene: Tg(Emx1-cre)1Ito  Location: unknown  
Alliance: Tg(Emx1-cre)1Ito page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Emx1-cre)1Ito expression driven by 1 gene
 
Mutation details: An Emx1 positive PAC clone frome the RPCI-21 PAC mouse genomic library (PAC-Emx1#1) was modified by the insertion of an NLS-Cre-poly(A) cassette into the NotI site by homologous recombination in bacteria. Two independent recombination events were identified. This transgenic line was generated from the PAC-Cre-A fragment and has 2-3 copies of the transgene. (J:88421)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Emx1 (mouse)
Summary of all recombinase alleles driven by Emx1.
 

Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Adult expression of this transgene is seen in the olfactory bulb, neocortex, piriform cortex, hippocampus and amygdala of the brain. At 7-8 days of age expression is also observed in the inferior colliculus. Activity is primarily in excitatory neurons and astrocytes. Little or no activity is seen in inhibitory neurons.
References
Original:  J:88421 Iwasato T, et al., Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice. Genesis. 2004 Mar;38(3):130-8
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory