Tg(NEFL-cre)50Msd Transgene Detail MGI Mouse (MGI:3702327)

Tg(NEFL-cre)50Msd
Transgene Detail

Summary

Symbol:	Tg(NEFL-cre)50Msd
Name:	transgene insertion 50, Michael Sendtner
MGI ID:	MGI:3702327
Synonyms:	NF-L-Cre
Transgene:	Tg(NEFL-cre)50Msd Location: unknown
Alliance:	Tg(NEFL-cre)50Msd page

Transgene
origin

Germline Transmission:	Earliest citation of germline transmission: J:77229
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Transgene
description

Transgene Type:

Transgenic (Recombinase)

Mutation:

Insertion

Tg(NEFL-cre)50Msd expression driven by 1 gene

Mutation details: 2kb of the human promoter and 3kb of downstream sequence were used to drive the expression of Cre in the brain and spinal cord. Two lines were created (lines 50 and 13) with only line 50 exhibiting expression. Crosses to a LacZ reporter strain was used to test the transgene insertion where by recombination resulted in neural LacZ expression. (J:77229)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	NEFL (human) Summary of all recombinase alleles driven by NEFL. Comparative matrix view of recombinase activities Alliance human NEFL gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

Original:	J:77229 Schweizer U, et al., Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult. J Cell Biol. 2002 Jan 21;156(2):287-97
All:	4 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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