Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Slc6a3tm1(cre)Lrsn
Name:	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1, Nils-Goran Larsson
MGI ID:	MGI:3702746
Synonyms:	DAT-cre
Gene:	Slc6a3  Location: Chr13:73684866-73726791 bp, + strand  Genetic Position: Chr13, 40.1 cM
Alliance:	Slc6a3tm1(cre)Lrsn page

Germline Transmission:	Earliest citation of germline transmission: J:119515
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Slc6a3tm1(cre)Lrsn expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Slc6a3 (MGI:94862)   Mutation details: Cre recombinase cDNA and an frt-flanked neo cassette was inserted into exon 2. Crossing with mice expressiong FLP recombinase in the germline removed the neo. These mice express cre recombinase in nigrostriatal dopamine neurons of the midbrain. (J:119515)

Activity:	Tissue activity of this recombinase allele
Driver:	Slc6a3 (mouse) Summary of all recombinase alleles driven by Slc6a3. Alliance mouse Slc6a3 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

52018 assay results 1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc6a3 Mutation:	66 strains or lines available

Original:	J:119515 Ekstrand MI, et al., Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1325-30
All:	64 reference(s)