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Rad51ctm1Sks
Targeted Allele Detail
Summary
Symbol: Rad51ctm1Sks
Name: RAD51 paralog C; targeted mutation 1, Shyam K Sharan
MGI ID: MGI:3707422
Synonyms: Rad51cneo
Gene: Rad51c  Location: Chr11:87267471-87295780 bp, - strand  Genetic Position: Chr11, 52.08 cM
Alliance: Rad51ctm1Sks page
Testes abnormalities in Rad51ctm1Sks/Rad51ctm1.1Sks mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119835
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutation:    Insertion
 
Mutation details: A floxed neo cassette is inserted between exon 1 and 2 with the addition of a loxP site 3' of exon 3 creating a hypomorphic allele. Aberrant splicing products were confirmed by RT-PCR and decreased protein production was confirmed by quantification of a western blots on mice testicular tissue. (J:119835)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 8 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Rad51ctm1Sks
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rad51c Mutation:  24 strains or lines available
References
Original:  J:119835 Kuznetsov S, et al., RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol. 2007 Feb 26;176(5):581-92
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory