Rad51c<tm1.1Sks> Targeted Allele Detail MGI Mouse (MGI:3707425)

Rad51c^tm1.1Sks
Targeted Allele Detail

Summary

Symbol:	Rad51c^tm1.1Sks
Name:	RAD51 paralog C; targeted mutation 1.1, Shyam K Sharan
MGI ID:	MGI:3707425
Synonyms:	Rad51c^ko
Gene:	Rad51c Location: Chr11:87267471-87295780 bp, - strand Genetic Position: Chr11, 52.08 cM
Alliance:	Rad51c^tm1.1Sks page

Testes abnormalities in Rad51c^tm1Sks/Rad51c^tm1.1Sks mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:119835
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: Exons 2 and 3 are removed by Cre-mediated recombination. The absence of protein product was confirmed by western blot analysis. (J:119835)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Rad51c^tm1.1Sks

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Rad51c Mutation:	24 strains or lines available

References

Original:	J:119835 Kuznetsov S, et al., RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol. 2007 Feb 26;176(5):581-92
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24