Chd7<Gt(S20-7E1)Sor> Gene trapped Allele Detail MGI Mouse (MGI:3707678)

Chd7^{Gt(S20-7E1)Sor}
Gene trapped Allele Detail

Summary

Symbol:	Chd7^{Gt(S20-7E1)Sor}
Name:	chromodomain helicase DNA binding protein 7; gene trap S20-7E1, Philippe Soriano
MGI ID:	MGI:3707678
Synonyms:	Chd7^Gt, Chd7^Gt1Dmm, Chd7^{Gt(FHCRC-GT-S20-7E1)Sor}, Chd7^{Gt(ROSAFARY)1Dmm}
Gene:	Chd7 Location: Chr4:8690406-8867659 bp, + strand Genetic Position: Chr4, 3.68 cM
Alliance:	Chd7^{Gt(S20-7E1)Sor} page

Abnormal development in Chd7^{Gt(S20-7E1)Sor}/Chd7^{Gt(S20-7E1)Sor} mice and delayed turning in Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ embryos

Show the 2 phenotype image(s) involving this allele.

Mutation
origin

Mutant Cell Line:	S20-7E1
Germline Transmission:	Earliest citation of germline transmission: J:119812
Parent Cell Line:	AK7.1 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: ROSAFARY

Mutation details: The gene trap vector ROSAFARY was inserted between exon 1 and 2 creating an exon 1/lacZ fusion transcript and an hyg fusion transcript with the remainder of the coding region. The absence of the normal splice product and the production of the two mutant variants was confirmed by RT-PCR. (J:119812)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	220 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	39 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Chd7 Mutation:	138 strains or lines available

References

Original:	J:119812 Hurd EA, et al., Loss of Chd7 function in gene-trapped reporter mice is embryonic lethal and associated with severe defects in multiple developing tissues. Mamm Genome. 2007 Feb;18(2):94-104
All:	19 reference(s)

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