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Ggcxtm1Dgi
Targeted Allele Detail
Summary
Symbol: Ggcxtm1Dgi
Name: gamma-glutamyl carboxylase; targeted mutation 1, David Ginsburg
MGI ID: MGI:3708899
Synonyms: Ggcx-
Gene: Ggcx  Location: Chr6:72391291-72407695 bp, + strand  Genetic Position: Chr6, 32.27 cM, cytoband C3
Alliance: Ggcxtm1Dgi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:120784
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
    A neomycin resistance gene was used to replace exons 3-13 of the gene. (J:120784)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ggcx Mutation:  37 strains or lines available
References
Original:  J:120784 Zhu A, et al., Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase. Blood. 2007 Jun 15;109(12):5270-5
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory