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Fh1tm1Pjp
Targeted Allele Detail
Summary
Symbol: Fh1tm1Pjp
Name: fumarate hydratase 1; targeted mutation 1, Patrick J Pollard
MGI ID: MGI:3710112
Synonyms: Fh1fl
Gene: Fh1  Location: Chr1:175428944-175453201 bp, - strand  Genetic Position: Chr1, 81.58 cM
Alliance: Fh1tm1Pjp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:120969
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A targeting vector was designed to flank exons 2 and 3 with loxP sites. An frt flanked neo was inserted downstream of the intron 3 loxP site. (J:120969)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fh1 Mutation:  37 strains or lines available
References
Original:  J:120969 Pollard PJ, et al., Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. Cancer Cell. 2007 Apr;11(4):311-9
All:  10 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory