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Tbx3tm1.1(cre)Vmc
Targeted Allele Detail
Summary
Symbol: Tbx3tm1.1(cre)Vmc
Name: T-box 3; targeted mutation 1.1, Vincent M Christoffels
MGI ID: MGI:3710254
Synonyms: Tbx3cre
Gene: Tbx3  Location: Chr5:119808734-119822789 bp, + strand  Genetic Position: Chr5, 60.34 cM
Alliance: Tbx3tm1.1(cre)Vmc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121230
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Tbx3tm1.1(cre)Vmc expression driven by 1 gene
 
Mutation details: A cre recombinase cDNA was inserted upstream to replace the first 3 codons in exon 1. A floxed neo was removed by Flp recombinase in the germline. (J:121230)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tbx3 (mouse)
Summary of all recombinase alleles driven by Tbx3.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx3 Mutation:  49 strains or lines available
References
Original:  J:121230 Hoogaars WM, et al., Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. Genes Dev. 2007 May 1;21(9):1098-112
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory