Epas1<tm1.1Mcs> Targeted Allele Detail MGI Mouse (MGI:3710344)

Epas1^tm1.1Mcs
Targeted Allele Detail

Summary

Symbol:	Epas1^tm1.1Mcs
Name:	endothelial PAS domain protein 1; targeted mutation 1.1, M Celeste Simon
MGI ID:	MGI:3710344
Synonyms:	Hif-2a^delta
Gene:	Epas1 Location: Chr17:87061292-87140838 bp, + strand Genetic Position: Chr17, 56.9 cM
Alliance:	Epas1^tm1.1Mcs page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:119731
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: Exon 2 was deleted by a recombination event when 3LoxP founders were crossed to Tg(EIIa-cre)C5379 mice to remove the floxed Neo cassette during creation of the floxed (tm1Mcs) allele. (J:119731)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Epas1^tm1.1Mcs

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Epas1 Mutation:	66 strains or lines available

References

Original:	J:119731 Gruber M, et al., Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2301-6
All:	4 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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